MilliporeSigma
All Photos(3)

Documents

H1512

Sigma-Aldrich

Haloperidol

powder

Sign Into View Organizational & Contract Pricing

Synonym(s):
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone
Empirical Formula (Hill Notation):
C21H23ClFNO2
CAS Number:
Molecular Weight:
375.86
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
0.1 M HCl: 3 mg/mL
DMSO: soluble
H2O: insoluble
ethanol: soluble

originator

Johnson & Johnson

SMILES string

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3

InChI

1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChI key

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
PHR17241303002BP407
Haloperidol powder

H1512

Haloperidol

Haloperidol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1724

Haloperidol

Haloperidol United States Pharmacopeia (USP) Reference Standard

1303002

Haloperidol

Haloperidol British Pharmacopoeia (BP) Reference Standard

BP407

Haloperidol

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL, DMSO: soluble, ethanol: soluble, 0.1 M HCl: 3 mg/mL, H2O: insoluble

solubility

-

solubility

-

solubility

-

originator

Johnson & Johnson

originator

-

originator

-

originator

-

color

white

color

-

color

-

color

-

Gene Information

human ... ABCB1(5243), ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), EBP(10682), HRH1(3269), HTR2A(3356), HTR2C(3358), HTR7(3363), KCNH1(3756), KCNH2(3757), PRNP(5621)
rat ... Adra1a(29412), Adra2a(25083), Chrm1(25229), Chrm2(81645), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2c(25187), Oprs1(29336), Slc6a3(24898), Slc6a4(25553)

Gene Information

human ... HTR2A(3356)

Gene Information

human ... HTR2A(3356)

Gene Information

human ... HTR2A(3356)

Application

Haloperidol has been used:
  • in ethanol to serves as an inhibitor of Erg2p
  • to address the mechanism of haloperidol in ferroptosis using hepatocellular carcinoma cells: Hep G2 and Huh-7 cell lines
  • in receptor internalization assay
  • as an antipsychotic drug in Dulbecco′s Modified Eagle medium

Biochem/physiol Actions

Haloperidol is a butyrophenone antipsychotic. It is also classified as a neuroleptic (powerful tranquilizer). Haloperidol acts as a D2, D3, and D4 dopamine receptor antagonist and thus causes Parkinson′s disorder. It also has a negative effect on the central nervous system.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 8

1 of 8

Haloperidol-D4 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

H-002

Haloperidol-D4 solution

PB28 dihydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

P9246

PB28 dihydrochloride

PRE-084 solid

Sigma-Aldrich

P2607

PRE-084

USP

USP

1303057

Haloperidol decanoate

Haloperidol metabolite II analytical standard

Supelco

H102

Haloperidol metabolite II

Paliperidone ≥98% (HPLC)

Sigma-Aldrich

P0099

Paliperidone

Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells
Bai T, et al.
Biochemical and Biophysical Research Communications, 491(4), 919-925 (2017)
Yeast sphingolipids do not need to contain very long chain fatty acids
Cerantola V, et al.
The Biochemical Journal, 401(1), 205-216 (2007)
CRC Desk Reference of Clinical Pharmacology null
Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling
Jeong J, et al.
Testing, 8(12), e84482-e84482 (2013)
Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells
Jiang L, et al.
BioMed Central Pharmacology, 9(1), 6-6 (2009)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service