MilliporeSigma

PDE4A

phosphodiesterase 4A, cAMP-specific

Synonyms:
DPDE2, PDE4, PDE46
Species:
UniProtKB ID:
Gene ID:
  • Human(5141) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(18577) phosphodiesterase 4A, cAMP specific
  • Rat(25638) phosphodiesterase 4A, cAMP-specific
  • sheep(101117505) phosphodiesterase 4A, cAMP-specific
  • Domestic Rabbit(100009247) phosphodiesterase 4A, cAMP-specific
  • Zebrafish(572061) phosphodiesterase 4A, cAMP-specific
  • domestic cat(751107) phosphodiesterase 4A, cAMP-specific
  • dog(100683695) phosphodiesterase 4A, cAMP-specific
  • chicken(769860) phosphodiesterase 4A, cAMP-specific
  • domestic guinea pig(100135594) phosphodiesterase 4A, cAMP-specific
  • cow(512222) phosphodiesterase 4A, cAMP-specific
  • naked mole-rat(101717168) phosphodiesterase 4A, cAMP-specific

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Activator

Product Number
Description
Species
Rolipram, solid, ≥98% (HPLC),
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid,
Species
human, rat
Theophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human
Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PDE4A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Ibudilast, ≥99% (HPLC), solid,
Species
human
Zaprinast, solid,
Species
human
Amlexanox, ≥98% (HPLC),
Species
human
Roflumilast, ≥98% (HPLC),
Species
human
Diprophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
PDE4A1A Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human
PDE4A10 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
Species
human
PDE4A4B active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PDE4A (3),
Species
human
MISSION® esiRNA, targeting human PDE4A,
Species
human
MISSION® esiRNA, targeting human PDE4A (2),
Species
human
MISSION® esiRNA, targeting mouse Pde4a,
Species
mouse