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1653004

USP

Theophylline

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

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About This Item

Empirical Formula (Hill Notation):
C7H8N4O2
CAS Number:
58-55-9
Molecular Weight:
180.16
Beilstein/REAXYS Number:
13463
MDL number:
MFCD00079619
UNSPSC Code:
41116107
PubChem Substance ID:
329751262
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

theophylline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1C(=O)N(C)c2[nH]cnc2C1=O

InChI

1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

InChI key

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Theophylline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Aminophylline
  • Aminophylline Delayed-Release Tablets
  • Aminophylline Injection
  • Aminophylline Oral Solution
  • Aminophylline Rectal Solution
  • Aminophylline Tablets
  • Dimenhydrinate

Biochem/physiol Actions

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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T0800000

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1653117

Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard

1077708

8-Bromotheophylline, United States Pharmacopeia (USP) Reference Standard

1653048

Theophylline Related Compound D, United States Pharmacopeia (USP) Reference Standard

1653037

Theophylline Related Compound C, United States Pharmacopeia (USP) Reference Standard

1653026

Theophylline Related Compound B, United States Pharmacopeia (USP) Reference Standard

1653060

Theophylline Related Compound F, United States Pharmacopeia (USP) Reference Standard

BP327

Theophylline, British Pharmacopoeia (BP) Reference Standard

PHR2588

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2541

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2551

Theophylline Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

1121038

8-Chlorotheophylline, United States Pharmacopeia (USP) Reference Standard

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Bing Dai et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 60(3), 360-370 (2012-04-21)
Whether treatment with adenosine receptor antagonists such as theophylline can prevent contrast-induced acute kidney injury (AKI) remains controversial. We conducted a meta-analysis of randomized controlled trials using MEDLINE (1966 to July 2011), EMBASE (1980 to July 2011), Web of Science
F S F Ram et al.
Respiratory medicine, 99(2), 135-144 (2005-02-18)
To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD.
Mazen Al-Alawi et al.
The American journal of medicine, 127(5), 370-378 (2014-01-02)
Global estimates on aging predict an increased burden of asthma in the older population. Consequently, its recognition, diagnosis, and management in clinical practice require optimization. This review aims to provide an update for clinicians, highlighting advances in the understanding of
Laura López-Cruz et al.
Behavioural brain research, 270, 213-222 (2014-05-27)
Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which are colocalized with dopamine D1 and D2 receptors in striatal areas.
Amy T Ma et al.
Applied and environmental microbiology, 80(21), 6704-6713 (2014-08-26)
Cyanobacteria are photosynthetic bacteria that are currently being developed as biological production platforms. They derive energy from light and carbon from atmospheric carbon dioxide, and some species can fix atmospheric nitrogen. One advantage of developing cyanobacteria for renewable production of
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