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USP

Acetaminophen

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Acetaminophen, 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

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About This Item

Linear Formula:
CH3CONHC6H4OH
CAS Number:
Molecular Weight:
151.16
Beilstein/REAXYS Number:
2208089
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

acetaminophen, paracetamol

manufacturer/tradename

USP

mp

168-172 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

Gene Information

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetaminophen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Acetaminophen Tablets
  • Acetaminophen Capsules
  • Acetaminophen Suppositories
  • Acetaminophen Oral Suspension
  • Acetaminophen Oral Solution
  • Acetaminophen and Caffeine Tablets
  • Acetaminophen Extended-Release Tablets

Analgesic.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Pricing

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

364.3 °F - Pensky-Martens closed cup

flash_point_c

184.6 °C - Pensky-Martens closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Acetaminophen
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(6), 38-38 (2020)
Acetaminophen capsules
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(3), 40-40 (2014)
Acetaminophen tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(3), 45-45 (2021)
Acetaminophen Suppositories
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(5), 44-44 (2016)
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure

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