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SML0517

Sigma-Aldrich

Amlexanox

≥98% (HPLC)

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Synonym(s):
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, AA 673, Amoxanox, CHX 3673
Empirical Formula (Hill Notation):
C16H14N2O4
CAS Number:
Molecular Weight:
298.29
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL at warmed, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

InChI

1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)

InChI key

SGRYPYWGNKJSDL-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
B2186SML0338SML1802
Amlexanox ≥98% (HPLC)

SML0517

Amlexanox

BL-1249 ≥98% (HPLC)

B2186

BL-1249

Lornoxicam ≥98% (HPLC)

SML0338

Lornoxicam

MS0015203 ≥98% (HPLC)

SML1802

MS0015203

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL at warmed, clear

solubility

DMSO: ~17.5 mg/mL, H2O: insoluble

solubility

DMSO: >5 mg/mL (warmed)

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

pink to brown

color

faintly yellow to dark yellow

color

white to beige

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

General description

Amlexanox is an anti-allergic drug with anti-inflammatory properties.

Biochem/physiol Actions

Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Brenda Murray et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 34(7), 413-419 (2005-07-14)
Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin. This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal (5% amlexanox paste) to determine if ulcer development could be prevented. A second
Sandhya G Rani et al.
Biochemistry, 49(11), 2585-2592 (2010-02-25)
S100A13 and acidic fibroblast growth factor (FGF1) are involved in a wide array of important biological processes, such as angiogenesis, cell differentiation, neurogenesis, and tumor growth. Generally, the biological function of FGF1 is to recognize a specific tyrosine kinase on
Ji Fu et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 113(5), 638-643 (2012-06-07)
The objective of this study was to evaluate the efficacy and safety of short-term and topical application of amlexanox paste in the treatment of erosive oral lichen planus (EOLP). A randomized, positive-controlled clinical trial was conducted from September 1 to
M Sugiura et al.
Contact dermatitis, 38(2), 65-67 (1998-03-20)
A 23-year-old woman developed allergic rhinitis in 1993. Her doctor prescribed for her Solfa (amlexanox 25 mg) and Lysozymen 90 (lysozyme chloride 90 mg) tablets. She took the tablets occasionally, whenever she developed allergic rhinitis. She noticed a macular erythema
M Rodríguez et al.
Oral diseases, 13(5), 490-494 (2007-08-24)
To compare the effectiveness of two topical medications to reduce the pain and size of recurrent minor aphthous ulcers. Ten Colombian Dental Faculties' clinics. A double-blind randomized multi-centre clinical study. Ninety-six patients complaining of at least five acute aphthous ulcers

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