MilliporeSigma

PDE4C

phosphodiesterase 4C, cAMP-specific

Synonyms:
DPDE1
Species:
UniProtKB ID:
Gene ID:
  • Human(5143) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(110385) phosphodiesterase 4C, cAMP specific
  • Rat(290646) phosphodiesterase 4C, cAMP-specific
  • dog(609938) phosphodiesterase 4C, cAMP-specific
  • cow(524624) phosphodiesterase 4C, cAMP-specific
  • domestic cat(101086123) phosphodiesterase 4C, cAMP-specific
  • naked mole-rat(101703048) phosphodiesterase 4C, cAMP-specific
  • sheep(101111282) phosphodiesterase 4C, cAMP-specific

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Small Molecule - Antagonist

Product Number
Description
Species
Aminophylline, ≥98%, powder,
Species
human
Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Theophylline, European Pharmacopoeia (EP) Reference Standard,
Species
human
Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline, phyproof® Reference Substance,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Monoclonal Anti-PDE4C, (N-terminal) antibody produced in mouse, clone 4E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-PDE4C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-PDE4C antibody produced in mouse, clone 6A10, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Amlexanox, ≥98% (HPLC),
Species
human
Roflumilast, ≥98% (HPLC),
Species
human
Ibudilast, ≥99% (HPLC), solid,
Species
human
Dyphylline, United States Pharmacopeia (USP) Reference Standard,
Species
human
7-(2,3-Dihydroxypropyl)theophylline, ,
Species
human

Proteins

Product Number
Description
Species
PDE4C1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Species
human
PDE4C Active from mouse, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Pde4c,
Species
mouse
MISSION® esiRNA, targeting human PDE4C,
Species
human