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PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

Synonyms:
PKACA
Species:
UniProtKB ID:
Gene ID:
  • Human(5566) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(18747) protein kinase, cAMP dependent, catalytic, alpha
  • Rat(25636) protein kinase, cAMP-dependent, catalytic, alpha
  • naked mole-rat(101707235) protein kinase, cAMP-dependent, catalytic, alpha
  • sheep(443094) protein kinase, cAMP-dependent, catalytic, alpha
  • domestic guinea pig(100735694) protein kinase, cAMP-dependent, catalytic, alpha
  • dog(403556) protein kinase, cAMP-dependent, catalytic, alpha
  • Horse(100064302) protein kinase, cAMP-dependent, catalytic, alpha
  • cow(282322) protein kinase, cAMP-dependent, catalytic, alpha
  • domestic cat(101090494) protein kinase, cAMP-dependent, catalytic, alpha

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PRKACA (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Application
immunohistochemistry
western blot
Anti-PRKACA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
ANTI-PKA C-ALPHA/PKA C-BETA(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-phospho-PKA α/β CAT (pThr197) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-Phospho-PRKACA-T197 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt, ≥90% (HPLC), lyophilized powder,
Species
mouse, rat, human
Tyrphostin A9, solid,
Species
mouse, human
Adenine, ≥99%,
Species
human, rat, mouse
Adenine, BioReagent, suitable for plant cell culture, ≥99%,
Species
human, rat, mouse
Adenine, BioReagent, suitable for cell culture,
Species
human, rat, mouse

Proteins

Product Number
Description
Species
Protein Kinase A catalytic subunit human, >90% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution,
Species
human
Protein Kinase A from bovine heart, ≥0.8 units/μg protein, lyophilized powder,
Species
cow

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PRKACA,
Species
human
MISSION® esiRNA, targeting mouse Prkaca,
Species
mouse