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MilliporeSigma

1.03893

SAFC

Benzenesulfonic acid

EMPROVE® EXPERT

Pharma Manufacturing

Synonym(s):

Benzene sulphonic acid, Benzenesulphonic acid, Besylic acid, Phenylsulfonic acid, Phenylsulphonic acid

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500 G
$2,415.00
1 KG
$4,038.00

$2,415.00


Availability

Estimated to ship onMarch 09, 2025


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500 G
$2,415.00
1 KG
$4,038.00

About This Item

Linear Formula:
C6H5SO3H
CAS Number:
Molecular Weight:
158.18
Beilstein/REAXYS Number:
742513
EC Number:
MDL number:
UNSPSC Code:
12352005

$2,415.00


Availability

Estimated to ship onMarch 09, 2025


Request a Bulk OrderRequest a Sample

biological source

synthetic

Quality Level

product line

EMPROVE® EXPERT

form

crystalline

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

impurities

endotoxins, low

application(s)

liquid formulation
parenterals
pharmaceutical

SMILES string

OS(=O)(=O)c1ccccc1

InChI

1S/C6H6O3S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H,7,8,9)

InChI key

SRSXLGNVWSONIS-UHFFFAOYSA-N

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1 of 4

This Item
8.0046812635135070
technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

crystalline

form

solid

form

solid

form

solid

product line

EMPROVE® EXPERT

product line

-

product line

-

product line

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

impurities

endotoxins, low

impurities

-

impurities

≤1.0% water

impurities

-

General description

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Benzenesulfonic Acid Emprove® Expert is part of this new proprietary technology platform.

Packaging

1038930500 / 500g / Glass bottle
1038931000 / 1kg / Glass bottle

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 1


  • What is the Emprove® Program?

    The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

    Material Qualification Dossier

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    Quality Management Dossier (Open Access)

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    Operational Excellence Dossier

    Available by subscription or for a fee

    Learn more about the benefits an Emprove® Program subscription can provide
    Why are these documents unavailable?
    Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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    Articles

    This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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