1.37117

Dimethyl sulfoxide

EMPROVE^® EXPERT, Ph. Eur., ChP, USP

• Synonym(s): Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO, DMSO
• Linear Formula: (CH₃)₂SO
• CAS Number: 67-68-5
• Molecular Weight: 78.13
• Beilstein: 506008
• MDL number: MFCD00002089
• EC Index Number: 200-664-3

Properties

• Agency: ChP; Ph. Eur.; USP
• Quality Level: 500
• vapor density: 2.7 (vs air)
• vapor pressure: 0.42 mmHg ( 20 °C)
• product line: EMPROVE^® EXPERT
• Assay: ≥99.9% (GC)
• form: liquid
• autoignition temp.: 573 °F
• expl. lim.: 42 %, 63 °F
• technique(s): API processing | polymorph screening: suitable
• refractive index: n20/D 1.479 (lit.)
• kinematic viscosity: 2.14 cSt
• bp: 189 °C (lit.)
• mp: 16-19 °C (lit.)
• transition temp: flash point 87 °C
• density: 1.10 g/mL (lit.)
• application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical; semi-solid formulation
• storage temp.: 2-30°C
• SMILES string: CS(C)=O
• InChI: 1S/C2H6OS/c1-4(2)3/h1-2H3
• InChI key: IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Dimethyl sulfoxide is used as penetration enhancer in topical formulation, as cryopreservative in cell therapy and solvent in antibody drug conjugate production.
Due to its low microbial and endotoxin limits, Dimethyl Sulfoxide Emprove^® Expert is especially suitable for high-risk applications.

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Specifications

8.0 g/m3 (20 °C)

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - closed cup
• Flash Point(C): 87 °C - closed cup