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49449

Sigma-Aldrich

L-Glutamic acid

BioUltra, ≥99.5% (NT)

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Synonym(s):
(S)-2-Aminopentanedioic acid, Glu
Linear Formula:
HO2CCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
147.13
Beilstein:
1723801
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product line

BioUltra

Quality Level

Assay

≥99.5% (NT)

form

powder

optical activity

[α]20/D +31.5±1.0°, c = 5% in 5 M HCl

impurities

insoluble matter, passes filter test
≤0.5% foreign amino acids

ign. residue

≤0.05% (as SO4)

loss

≤0.05% loss on drying, 20 °C (HV)

color

white

mp

205 °C (dec.) (lit.)

solubility

1 M HCl: 1 M at 20 °C, clear, colorless

density

1.54 g/cm3 at 20 °C

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in 1 M HCl

UV absorption

λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1

application(s)

cell analysis

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

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This Item
G8415W328502PHL82551
L-Glutamic acid BioUltra, ≥99.5% (NT)

Sigma-Aldrich

49449

L-Glutamic acid

Premium Grade
L-Glutamic acid from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

Sigma-Aldrich

G8415

L-Glutamic acid

-
L-Glutamic acid FCC

Sigma-Aldrich

W328502

L-Glutamic acid

-
L-Glutamic acid phyproof® Reference Substance

PHL82551

L-Glutamic acid

-
assay

≥99.5% (NT)

assay

98.5-100.5%

assay

98.5-101.5% dry basis (perchloric acid titration)

assay

≥98.0% (HPLC)

form

powder

form

powder

form

powder or crystals

form

solid

optical activity

[α]20/D +31.5±1.0°, c = 5% in 5 M HCl

optical activity

-

optical activity

[α]20/D +32°, c = 10 in 2 M HCl

optical activity

-

impurities

insoluble matter, passes filter test, ≤0.5% foreign amino acids

impurities

endotoxin, tested

impurities

-

impurities

-

color

white

color

white

color

-

color

-

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Other Notes

Lesion-sparing agent, has excitotoxic properties; May function as precipitating agent in protein crystallization; Growth requirement of various microorganisms

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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CRC Handbook of Microbiology, 4, 1-1 (1974)
Excitotoxic amino acids as neuroendocrine research tools.
J W Olney et al.
Methods in enzymology, 103, 379-393 (1983-01-01)
Protein crystallization: the growth of large-scale single crystals.
G L Gilliland et al.
Methods in enzymology, 104, 370-381 (1984-01-01)
Steffen Gonda et al.
Frontiers in neuroanatomy, 14, 571351-571351 (2020-12-08)
NMDA receptors are important players for neuronal differentiation. We previously reported that antagonizing NMDA receptors with APV blocked the growth-promoting effects evoked by the overexpression of specific calcium-permeable or flip-spliced AMPA receptor subunits and of type I transmembrane AMPA receptor
Luigi F Agnati et al.
Pharmacological reviews, 55(3), 509-550 (2003-07-19)
The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers. The discovery of GABAB heterodimers started this field rapidly followed by

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