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81709

Sigma-Aldrich

L-Proline

≥99.5% (NT), suitable for cell culture, BioUltra

Synonym(s):

(S)-Pyrrolidine-2-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C5H9NO2
CAS Number:
147-85-3
Molecular Weight:
115.13
Beilstein:
80810
EC Number:
205-702-2
MDL number:
MFCD00064318
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57652885
NACRES:
NA.26

Product Name

L-Proline, BioUltra, ≥99.5% (NT)

product line

BioUltra

Assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D −85.0±1.0°, c = 5% in H2O

technique(s)

cell culture | mammalian: suitable

impurities

insoluble matter, passes filter test
≤0.3% foreign amino acids

ign. residue

≤0.1%

loss

≤0.1% loss on drying, 20 °C (HV)

color

colorless to white

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Application


  • Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (M(pro)).: This publication discusses the synthesis of novel compounds using L-Proline and their potential as inhibitors against COVID-19, contributing to the ongoing search for effective treatments (Geedkar et al., 2024).

Other Notes

Protects enzymes against heat inactivation; Growth requirement of various microorganisms

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6256
BCCG6255
BCBZ5040
BCBP4505V
BCBJ3904V

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CRC Handbook of Microbiology, 4, 1-1 (1974)
L.G. Paleg et al.
Australian Journal of Plant Physiology, 8, 107-107 (1981)
Marie Couturier et al.
The Journal of biological chemistry, 288(20), 14624-14635 (2013-04-06)
The microbial deconstruction of the plant cell wall is a key biological process that is of increasing importance with the development of a sustainable biofuel industry. The glycoside hydrolase families GH5 (PaMan5A) and GH26 (PaMan26A) endo-β-1,4-mannanases from the coprophilic ascomycete
Michael P Manns et al.
Gastroenterology, 147(2), 366-376 (2014-04-15)
MK-5172 is an inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A protease; MK-5172 is taken once daily and has a higher potency and barrier to resistance than licensed protease inhibitors. We investigated the efficacy and tolerability of MK-5172
David Saadoun et al.
Annals of the rheumatic diseases, 73(5), 831-837 (2013-04-23)
The standard-of-care treatment of patients with hepatitis C virus (HCV)-mixed cryoglobulinemia (MC) vasculitis includes pegylated interferon α (PegIFN)-α plus ribavirin and/or rituximab. About 30-40% of patients are non-responders or relapsers to such combination. To analyse the safety and efficacy of
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Articles

Proline Derivatives and Analogs

Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.

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