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61819

Sigma-Aldrich

L-Leucine

BioUltra, ≥99.5% (NT)

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Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721722
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product line

BioUltra

Quality Level

assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D +15.5±0.5°, c = 5% in 5 M HCl

technique(s)

NMR: suitable

impurities

insoluble matter, passes filter test
≤0.3% foreign amino acids

ign. residue

≤0.1%

loss

≤0.1% loss on drying, 20 °C (HV)

color

white

mp

>300 °C (lit.)

solubility

1 M HCl: 0.1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤200 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.1 M in 1 M HCl

UV absorption

λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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This Item
L8912W329703L8000
vibrant-m

61819

L-Leucine

Premium Grade
vibrant-m

L8912

L-Leucine

-
vibrant-m

W329703

L-Leucine

-
vibrant-m

L8000

L-Leucine

Essential Grade
technique(s)

NMR: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

ligand binding assay: suitable

form

powder or crystals

form

powder

form

-

form

powder

product line

BioUltra

product line

-

product line

-

product line

-

impurities

insoluble matter, passes filter test, ≤0.3% foreign amino acids

impurities

endotoxin, tested

impurities

-

impurities

isoleucine and methionine, essentially free

color

white

color

white

color

-

color

white to off-white

Other Notes

As spacer in isotachophoresis of serum proteins; Growth requirement of various microorganisms

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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L-Leucine Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1105

L-Leucine

T. Hine
Electrophoresis ?83, 541-541 null
T. Yagi et al. et al.
Electrophoresis ?83, 503-503 (1984)
CRC Handbook of Microbiology, 4, 1-1 (1974)
Youwen Qiu et al.
Journal of agricultural and food chemistry, 67(32), 8884-8895 (2019-07-28)
Leucine is an essential amino acid in the milk production of bovine mammary glands, but the regulatory roles and molecular mechanisms of leucine are still not known well. This study investigated the roles of leucine on milk synthesis and explored
Qian Wang et al.
Journal of the National Cancer Institute, 105(19), 1463-1473 (2013-09-21)
L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for

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