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L8000

Sigma-Aldrich

L-Leucine

reagent grade, ≥98% (HPLC)

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Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721722
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

grade

reagent grade

Quality Level

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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1 of 4

This Item
61819L8912W329703
vibrant-m

L8000

L-Leucine

Essential Grade
vibrant-m

61819

L-Leucine

Premium Grade
vibrant-m

L8912

L-Leucine

-
vibrant-m

W329703

L-Leucine

-
assay

≥98% (HPLC)

assay

≥99.5% (NT)

assay

98.5-101.0%

assay

99%

technique(s)

ligand binding assay: suitable

technique(s)

NMR: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

form

powder

form

powder or crystals

form

powder

form

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

color

white to off-white

color

white

color

white

color

-

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan
Journal of Translational Medicine (2015)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
Sergio R Santa Maria et al.
Astrobiology (2020-01-07)
The biological risks of the deep space environment must be elucidated to enable a new era of human exploration and scientific discovery beyond low earth orbit (LEO). There is a paucity of deep space biological missions that will inform us

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