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L8000

Sigma-Aldrich

L-Leucine

≥98% (HPLC), suitable for ligand binding assays

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Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721722
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

grade

reagent grade

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan
Journal of Translational Medicine (2015)
Sergio R Santa Maria et al.
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The biological risks of the deep space environment must be elucidated to enable a new era of human exploration and scientific discovery beyond low earth orbit (LEO). There is a paucity of deep space biological missions that will inform us

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