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About This Item
Empirical Formula (Hill Notation):
C50H73N15O11 · xC2H4O2
CAS Number:
Molecular Weight:
1060.21 (free base basis)
EC Number:
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.32
grade:
for analytical purposes
form:
powder
solubility:
0.1 M acetic acid: 25 mg/mL, clear, colorless
Recommended Products
grade
for analytical purposes
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
0.1 M acetic acid: 25 mg/mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
SMILES string
N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
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Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Application
Bradykinin acetate salt has been used:
- to stimulate the contraction of guinea pig ileum
- as a contractile agent in fibroblasts
- In the stimulation of endothelium of human subcutaneous artery
- To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15
Biochem/physiol Actions
Activates pain receptors; induces smooth muscle contraction; activates Ca2+-dependent nitric oxide synthetase; increases capillary permeability.
Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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