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A9650

Sigma-Aldrich

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

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Synonym(s):
5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
Empirical Formula (Hill Notation):
C62H89N17O14 · xC2H4O2 · yH2O
CAS Number:
Molecular Weight:
1296.48 (anhydrous free base basis)
MDL number:
eCl@ss:
42020611
PubChem Substance ID:
NACRES:
NA.32

biological source

human

Quality Level

assay

≥90% (HPLC)

form

powder

mol wt

1296 Da by calculation (Average Mass)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

cell culture | mammalian: suitable

solubility

acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1

InChI key

CKIFOTYDIFUKEP-AUVUXLIHSA-N

Gene Information

human ... AGT(183)

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Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

General description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling

Application

Angiotensin I human acetate salt hydrate has been used:
  • as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
  • to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
  • as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH3COOH.6H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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