S6883

Substance P acetate salt hydrate

≥95% (HPLC), powder

• Empirical Formula (Hill Notation): C₆₃H₉₈N₁₈O₁₃S · xC₂H₄O₂ · yH₂O
• CAS Number: 137348-11-9
• Molecular Weight: 1347.63 (anhydrous free base basis)
• Beilstein/REAXYS Number: 5153552
• UNSPSC Code: 12352200
• PubChem Substance ID: 24899725
• NACRES: NA.32

Properties

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• mol wt: 1348 Da by calculation (Average Mass)
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white
• solubility: 0.1 M acetic acid: 1 mg/mL
• UniProt accession no.: P20366
• storage temp.: −20°C
• SMILES string: [H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

Description

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

General description

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Application

Substance P acetate salt hydrate has been:

• used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
• administered in central nucleus (ACE) in rat to study its positive reinforcing effects
• used in competition binding assays
• used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent.

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)