C0292
Calcitonin Gene Related Peptide rat
≥95% (HPLC), powder
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biological source
rat
Quality Level
assay
≥95% (HPLC)
form
powder
mol wt
3803.25-3809.25 Da
technique(s)
cell based assay: suitable
sequence note
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
storage temp.
−20°C
Gene Information
rat ... Calca(24241)
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Amino Acid Sequence
General description
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
Application
- To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).
- To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.
- To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor.
Biochem/physiol Actions
Other Notes
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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