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C0292

Sigma-Aldrich

Calcitonin Gene Related Peptide rat

≥95% (HPLC), powder

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Synonym(s):
α-CGRP, CGRP-I
Empirical Formula (Hill Notation):
C162H262N50O52S2
CAS Number:
Molecular Weight:
3806.25
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

rat

Quality Level

assay

≥95% (HPLC)

form

powder

mol wt

3803.25-3809.25 Da

technique(s)

cell based assay: suitable

sequence note

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2

UniProt accession no.

storage temp.

−20°C

Gene Information

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Amino Acid Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2

General description

Research area: Neuroscience

Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.

Application

Calcitonin Gene Related Peptide rat has been used:
  • To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).
  • To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.
  • To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor.

Biochem/physiol Actions

Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system, thereby exerting its role in regulating pain and cardiovascular activity. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation and are associated with hyperemia. It stimulates edema in orofacial tissue and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells.
Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.

Other Notes

Lyophilized from 0.1% TFA in H2O

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Effect of calcitonin gene-related peptide on anastomotic healing in the presence of endotoxin
Dogmucs M, et al.
ANZ Journal of Surgery, 75(12), 1106-1110 (2005)
Effects of salmon calcitonin and calcitonin gene related peptide (CGRP) on gastric mucosal barrier in stress induced rats
Kanay Z, et al.
African Journal of Biotechnology, 8(8) (2009)
Calcitonin gene-related peptide: physiology and pathophysiology
F A Russell, et al.
Physiological Reviews, 94(4), 1099-1142 (2014)
Exogenous alpha-calcitonin gene-related peptide attenuates lipopolysaccharide-induced acute lung injury in rats
Yang W, et al.
Molecular Medicine Reports, 12(2), 2181-2188 (2015)
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors
Warwick CA, et al.
Pain, 160(3), 702-711 (2019)

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