Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

47608

Sigma-Aldrich

Formaldehyde solution

for molecular biology, BioReagent, ≥36.0% in H2O (T)

Synonym(s):

Formic aldehyde, Formol, Formalin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
HCHO
CAS Number:
50-00-0
Molecular Weight:
30.03
Beilstein:
1209228
MDL number:
MFCD00003274
UNSPSC Code:
12352114
PubChem Substance ID:
329757328
NACRES:
NA.52
grade:
Molecular Biology
for molecular biology
technique(s):
electrophoresis: suitable
vapor pressure:
52 mmHg ( 37 °C)
Pricing and availability is not currently available.

grade

Molecular Biology
for molecular biology

Quality Level

100

vapor density

1.03 (vs air)

vapor pressure

52 mmHg ( 37 °C)

product line

BioReagent

form

liquid

autoignition temp.

572 °F

contains

~10% methanol as stabilizer

concentration

≥36.0% in H2O (T)
36.0-38.0% (aldehyde method)

technique(s)

electrophoresis: suitable

Looking for similar products? Visit Product Comparison Guide

General description

Formaldehyde is a molecular biology reagent that denaturates RNA during electrophoresis when incorporated in agarose gels.
It is an aliphatic aldehyde that is widely used in industrial applications for the synthesis of several chemicals such as melamine formaldehyde, urea-formaldehyde, phenol formaldehyde and industrial resins, paraformaldehyde, polyols, chelating agents, slow release fertilizers, 1,4-butanediol and hexamethylenetetramine.[1]

Application

Formaldehyde solution is suitable for:
  • denaturation and separation of RNA molecules
  • anti-bacterial treatment
  • fixation of cells
Formaldehydesolution has been used:
  • in the fixation of human spermatogonial stem cell transplantation (SSCT).[2]
  • to crosslink T- cell acute lymphoblastic leukemia protein/DNA complex during chromatin immunoprecipitation.[3]
  • in fixing zebra fish larvae for neutrophil staining.[4]

Caution

may contain precipitate (paraformaldehyde)

Principle

Formaldehyde disrupts the secondary structure of RNA and allows separation and identification of RNA species based on charge migration.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

Target Organs

Eyes,Central nervous system, Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

133.0 °F - closed cup

Flash Point(C)

56.11 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCM0733
BCCL7726
BCCL1095
BCCK6291
BCCK9092

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Testicular tissue cryopreservation is the preferred method to preserve spermatogonial stem cells prior to transplantation
Onofre J, et al.
Reproductive Biomedicine Online, 40(2), 261-269 (2020)
Formaldehyde
Gerberich, H R and Seaman, G C.
Kirk-Othmer Encyclopedia of Chemical Technology (2013)
Jin Qian et al.
Virology, 474, 10-18 (2014-12-03)
Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins
Dannis G van Vuurden et al.
Neuro-oncology, 16(7), 946-959 (2014-01-29)
Glial brain tumors cause considerable mortality and morbidity in children and adults. Innovative targets for therapy are needed to improve survival and reduce long-term sequelae. The aim of this study was to find a candidate tumor-promoting protein, abundantly expressed in
Y Jiang et al.
Oncogene, 34(50), 6079-6091 (2015-03-10)
Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epithelial carcinomas such as nasopharyngeal carcinoma (NPC). EBV can epigenetically reprogram lymphocyte-specific processes and induce cell immortalization.
View All Related Papers

Articles

Cellular Fluorescence Imaging with Millicell® Cell Culture Inserts

Millicell® hanging cell culture inserts for staining and microscopic analysis directly from the insert. Learn to utilize hanging cell culture inserts in barrier measurements.

3D Organoid Culture: New In Vitro Models of Development and Disease

Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service