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Merck

08012

Supelco

1-デオキシノジリマイシン

analytical standard

別名:

1,5-ジデオキシ-1,5-イミノ-D-ソルビトール

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About This Item

実験式(ヒル表記法):
C6H13NO4
CAS番号:
分子量:
163.17
Beilstein:
3588039
MDL番号:
UNSPSCコード:
85151701
PubChem Substance ID:
NACRES:
NA.24

グレード

analytical standard

品質水準

アッセイ

≥95.0% (HPLC)

シェルフライフ

limited shelf life, expiry date on the label

フォーマット

neat

SMILES記法

OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI Key

LXBIFEVIBLOUGU-JGWLITMVSA-N

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詳細

1-Deoxynojirimycin is a polyhydroxypiperidine alkaloid and glucose analog, that has an -NH group substituting the O atom in the pyranose ring. It shows a significant α-glucosidase inhibitory effect in addition to antioxidant, antimicrobial, antidiabetic, antitumor, and anti-inflammatory behavior. It is commonly found in the roots of mulberry trees.

アプリケーション

DNJ may be used as a reference standard for the determination of DNJ in:
  • Mulberry leaves by high-performance liquid chromatography (HPLC) equipped with evaporative light scattering detector (ELSD) as well as direct analysis in real-time (DART) ionization source coupled with triple quadrupole tandem mass spectrometry (MS/MS).
  • Silkworms by hydrophilic interaction chromatography (HILIC) with MS/MS operating on multiple reaction monitoring (MRM) mode.
  • Mulberry leaves of 132 varieties belonging to nine Morus species following its derivatization with fluorenylmethyl chloroformate (FMOC-Cl) by high-performance liquid chromatography (HPLC) combined with photodiode array (PDA) detector
  • Development of an analytical method based on hydrophilic interaction chromatography (HILIC) coupled with tandem mass spectrometry (MS/MS) in positive ion electrospray ionization mode in the leaves of 32 cultivars of different Morus species
  • HPLC method-based separation and quantification in the ethanol extracts of the leaves of Morus alba L. and Morus nigra with fluorimetric detection following pre-column derivatization with 9-fluorenylmethyl chloroformate
  • 146 varieties of mulberry fruits from nine genera by HPLC in combination with UV-Vis dual-wavelength detection
  • Human plasma by hybrid quadrupole/linear ion trap tandem mass spectrometry (QTRAP MS/MS).

保管分類コード

11 - Combustible Solids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

08012-BULK:
08012-VAR:
08012-10MG:


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Katsumi Higaki et al.
Future medicinal chemistry, 5(13), 1551-1558 (2013-09-13)
A growing body of evidence suggests that misfolding of a mutant protein followed by its aggregation or premature degradation in the endoplasmic reticulum is one of the main mechanisms that underlie inherited neurodegenerative diseases, including lysosomal storage diseases. Chemical or
Daisuke Kitano et al.
Cardiovascular diabetology, 12, 92-92 (2013-06-20)
Hyperglycemia, a risk factor for development of cardiovascular disease, causes endothelial dysfunction. Alpha-glucosidase inhibitors (α-GIs) improve postprandial hyperglycemia (PPHG) and may have favorable effects on associated cardiovascular disease. Effects of α-GIs in patients with acute coronary syndrome (ACS) and PPHG
Danielle te Vruchte et al.
The Journal of clinical investigation, 124(3), 1320-1328 (2014-02-04)
Lysosomal storage disorders (LSDs) occur at a frequency of 1 in every 5,000 live births and are a common cause of pediatric neurodegenerative disease. The relatively small number of patients with LSDs and lack of validated biomarkers are substantial challenges
Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry
Nuengchamnong N, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(4), 853-858 (2007)
Bi-Qing Li et al.
PloS one, 8(6), e65207-e65207 (2013-06-14)
Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from

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