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Fmoc chloride

≥99.0%, for HPLC derivatization, LiChropur

Synonym(s):

9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl

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About This Item

Empirical Formula (Hill Notation):
C15H11ClO2
CAS Number:
Molecular Weight:
258.70
Beilstein/REAXYS Number:
2279177
EC Number:
MDL number:
UNSPSC Code:
41115710
PubChem Substance ID:
NACRES:
NA.22

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Product Name

Fmoc chloride, LiChropur, ≥99.0% (HPLC)

grade

derivatization grade ((HPLC))

Quality Level

assay

≥99.0% (HPLC)

form

solid

quality

LiChropur

technique(s)

HPLC: suitable

mp

61-64 °C
62-64 °C (lit.)

storage temp.

2-8°C

SMILES string

ClC(=O)OCC1c2ccccc2-c3ccccc13

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General description

Fmoc chloride is a derivatizing agent.

Application

Fmoc chloride may be used as derivatizing reagent in pre-column derivatization of the biogenic amines, resolved using HPLC technique.[1]
Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.

Other Notes

Reagent for precolumn derivatization of amines for HPLC and fluorescent detection (abs.: 265 nm, em.: 315 nm)[2][3][4]; Used for capillary electrophoresis[5]

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

supp_hazards

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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J.V. Sancho et al.
Journal of Chromatography A, 678, 59-59 (1994)
K C Chan et al.
Journal of chromatography. A, 653(1), 93-97 (1993-10-29)
Laser-induced fluorescence (LIF) was applied to the detection of 9-fluorenylmethyl chloroformate (FMOC-Cl) derivatized amino acids separated by capillary electrophoresis. Fluorescence excitation was provided by a pulsed, KrF laser operating at 248 nm. A limit of detection of 5 x 10(-10)
J. Kirschbaum et al.
Journal of Chromatography A, 661, 193-193 (1994)
S. Einarsson et al.
Analytical Chemistry, 58, 1638-1638 (1986)
Guoying Cao et al.
The Journal of antimicrobial chemotherapy, 62(5), 1009-1014 (2008-09-04)
The purpose of this study was to develop a specific, sensitive, accurate and reproducible high-performance liquid chromatographic (HPLC) method to measure polymyxin B in human plasma. Derivatization of polymyxin B with fluorescent 9-fluorenylmethyl chloroformate (FMOC-Cl) was performed in the same

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