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Fmoc chloride

≥99.0%, for HPLC derivatization, LiChropur

Synonym(s):

9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl

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About This Item

Empirical Formula (Hill Notation):
C15H11ClO2
CAS Number:
Molecular Weight:
258.70
Beilstein/REAXYS Number:
2279177
EC Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

product name

Fmoc chloride, for HPLC derivatization, LiChropur, ≥99.0% (HPLC)

grade

for HPLC derivatization

Quality Level

assay

≥99.0% (HPLC)

form

solid

quality

LiChropur

technique(s)

HPLC: suitable

mp

61-64 °C
62-64 °C (lit.)

storage temp.

2-8°C

SMILES string

ClC(=O)OCC1c2ccccc2-c3ccccc13

InChI

1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2

InChI key

IRXSLJNXXZKURP-UHFFFAOYSA-N

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General description

Fmoc chloride is a derivatizing agent.

Application

Fmoc chloride may be used as derivatizing reagent in pre-column derivatization of the biogenic amines, resolved using HPLC technique.
Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.

Other Notes

Reagent for precolumn derivatization of amines for HPLC and fluorescent detection (abs.: 265 nm, em.: 315 nm); Used for capillary electrophoresis

Recommended products

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

supp_hazards

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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K C Chan et al.
Journal of chromatography. A, 653(1), 93-97 (1993-10-29)
Laser-induced fluorescence (LIF) was applied to the detection of 9-fluorenylmethyl chloroformate (FMOC-Cl) derivatized amino acids separated by capillary electrophoresis. Fluorescence excitation was provided by a pulsed, KrF laser operating at 248 nm. A limit of detection of 5 x 10(-10)
J.V. Sancho et al.
Journal of Chromatography A, 678, 59-59 (1994)
J. Kirschbaum et al.
Journal of Chromatography A, 661, 193-193 (1994)
S. Einarsson et al.
Analytical Chemistry, 58, 1638-1638 (1986)
Bahareh Mohammadi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 12-18 (2011-12-17)
In High Performance Liquid Chromatographic (HPLC) determination of chemicals with acidic functions, different labeling agents are used to improve sensitivity of the assay. 9-Fluorenylmethyl chloroformate (FMOC-Cl), on the other hand, is a suitable labeling agent, which reacts with both primary

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