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Iridium-catalyzed asymmetric hydrogenation of olefins.

Iridium-catalyzed asymmetric hydrogenation of olefins.

Accounts of chemical research (2007-08-04)

Stephen J Roseblade, Andreas Pfaltz

要旨

Asymmetric hydrogenation is one of the most important catalytic methods for the preparation of optically active compounds. For a long time the range of olefins that could be hydrogenated with high enantiomeric excess was limited to substrates bearing a coordinating group next to the C+C bond. We have found a new class of catalysts, iridium complexes with chiral P, N ligands, that overcome these limitations. For a wide range of unfunctionalized olefins, excellent enantioselectivities could be achieved. Because these catalysts do not require the presence of any particular functional group in the substrate, they considerably broaden the scope of asymmetric hydrogenation. In addition, promising results were also obtained with certain functionalized alkenes, furans, and benzofurans.

材料

製品番号

ブランド

製品内容

Sigma-Aldrich

イリジウム, powder, 99.9% trace metals basis

Sigma-Aldrich

イリジウム, foil, thickness 0.25 mm, 99.9% trace metals basis

Sigma-Aldrich

イリジウム, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.9% trace metals basis

イリジウム, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.9%

イリジウム, wire reel, 0.5m, diameter 0.38mm, as drawn, 99.9%

イリジウム, rod, 25mm, diameter 3.0mm, as drawn, 99.9%

イリジウム, rod, 25mm, diameter 2.0mm, as drawn, 99.9%

イリジウム, rod, 50mm, diameter 2.0mm, as drawn, 99.9%

イリジウム, foil, 25x25mm, thickness 0.125mm, as rolled, 99.9%

イリジウム, wire, straight, 100mm, diameter 0.5mm, as drawn, 99.9%

イリジウム, wire reel, 0.05m, diameter 0.8mm, as drawn, 99.9%

イリジウム, foil, 25x25mm, thickness 0.15mm, as rolled, 99.9%

イリジウム, foil, 0.025m coil, thickness 0.05mm, coil width .5mm, as rolled, 99.9%

イリジウム, microfoil, disks, 10mm, thinness 0.1μm, specific density 224μg/cm², permanent mylar 3.5μm support, 99.9%

イリジウム, rod, 50mm, diameter 3.0mm, as drawn, 99.9%

イリジウム, wire reel, 1m, diameter 0.125mm, as drawn, 99.9%

イリジウム, microfoil, disks, 25mm, thinness 0.1μm, specific density 224μg/cm², permanent mylar 3.5μm support, 99.9%

イリジウム, wire reel, 0.05m, diameter 0.1mm, as drawn, 99.9%

イリジウム, wire reel, 0.1m, diameter 0.15mm, as drawn, 99.9%

イリジウム, foil, 25x25mm, thickness 0.25mm, as rolled, 99.9%

イリジウム, foil, 0.1m coil, thickness 0.05mm, coil width .5mm, as rolled, 99.9%

イリジウム, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.9%

イリジウム, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%

イリジウム, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.5%

イリジウム, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.9%

イリジウム, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.9%

イリジウム, wire reel, 0.3m, diameter 0.5mm, as drawn, 99.9%

イリジウム, wire reel, 2m, diameter 0.125mm, as drawn, 99.9%

イリジウム, wire, straight, 200mm, diameter 0.5mm, as drawn, 99.9%

イリジウム, wire, straight, 50mm, diameter 1.0mm, as drawn, 99.9%