コンテンツへスキップ

Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy.

Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2014-07-24)

Vania B Rezende, Fernando Barbosa, Ana C Palei, Ricardo C Cavalli, Jose E Tanus-Santos, Valeria C Sandrim

要旨

Although a number of studies have measured circulating levels of some trace elements in preeclampsia (PE) and compared to healthy pregnant (HP), there is no consensus yet about the deficiency of some metals and development of hypertensive disorders in pregnancy. The aim of this study was to compare plasmatic levels of Zn, Mn, Co, Cu, Se and Sr among non-pregnant (NP), healthy pregnant (HP), gestational hypertensive (GH) and preeclamptic (PE) women and to correlate these levels with plasma soluble endoglin (sENG) and soluble fms-like tyrosine kinase-1 (sFLT-1), two important antiangiogenic proteins related to PE. A total of 184 women were enrolled in this study (NP=35, GH=51, PE=37 and HP=61). Trace element analyses were carried out with an inductively coupled plasma mass spectrometer (ICPMS). sENG and sFLT-1 plasma concentrations were measured by commercial ELISA kits. The most interesting result is that Sr is higher in PE (63%, P<0.001) compared to HP and their levels are positively correlated with sENG in all three groups of pregnant women. Moreover, we found a negative correlation between Zn and sENG in HP (r=-0.43, P=0.003). Regarding other elements, we found similar levels among pregnant groups. In conclusion, this study showed that Sr may has a role in physiopathology of PE.

材料

製品番号

ブランド

製品内容

Sigma-Aldrich

ロジウム, powder, 99.95% trace metals basis

Sigma-Aldrich

硝酸ロジウム(III) 溶液, ~10 % (w/w) (Rh in >5 wt. % HNO₃)

Sigma-Aldrich

イットリウム, chips, 99.9% trace rare earth metals basis

Sigma-Aldrich

イットリウム, diam. × thickness 2.00 in. × 0.25 in., 99.9% trace metals basis

ロジウム, wire reel, 0.05m, diameter 0.5mm, as drawn, 99.9%

ロジウム, foil, 25x25mm, thickness 0.15mm, as rolled, 99.9%

イットリウム, wire reel, 0.1m, diameter 0.5mm, 99.9%

イットリウム, foil, 25mm disks, thickness 0.50mm, as rolled, 99%

ロジウム, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%

ロジウム, foil, 25x25mm, thickness 0.125mm, as rolled, 99.9%

ロジウム, foil, 25x25mm, thickness 0.1mm, as rolled, 99.9%

ロジウム, wire reel, 0.5m, diameter 0.25mm, hard, 99.9%

イットリウム, wire reel, 0.05m, diameter 0.5mm, 99.9%

ロジウム, microfoil, disks, 25mm, thinness 0.1μm, specific density 124μg/cm², permanent mylar 3.5μm support, 99.9%

ロジウム, wire reel, 0.05m, diameter 0.25mm, hard, 99.9%

イットリウム, rod, 50mm, diameter 2.0mm, cast, 99%

イットリウム, rod, 50mm, diameter 6.35mm, cast, 99%

ロジウム, microfoil, disks, 10mm, thinness 0.1μm, specific density 124μg/cm², permanent mylar 3.5μm support, 99.9%

ロジウム, microfoil, disks, 10mm, thinness 0.50μm, specific density 620μg/cm², permanent mylar 3.5μm support, 99.99%

イットリウム, rod, 50mm, diameter 12.5mm, cast, 99%

ロジウム, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, x-ray quality, 99.9%

ロジウム, foil, not light tested, 25x25mm, thickness 0.0005mm, permanent polyester support, 99.85%

ロジウム, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.9%

イットリウム, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%

イットリウム, wire reel, 0.05m, diameter 1.0mm, 99.9%

ロジウム, foil, not light tested, 10x10mm, thickness 0.012mm, as rolled, 99.9%

Supelco

4-tert-オクチルフェノールモノエトキシラート溶液, 10 μg/mL in acetone, analytical standard

ロジウム, foil, not light tested, 25x25mm, thickness 0.00075mm, permanent polyester support, 99.85%

ロジウム, wire reel, 0.1m, diameter 1.0mm, as drawn, 99.9%

イットリウム, rod, 100mm, diameter 12.5mm, cast, 99%