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Merck

104662

SAFC

Cellvento® ModiFeed Sial+ COMP

new
greener alternative

Chemically defined cell culture feed - EMPROVE® CCM

Pharma Manufacturing

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About This Item

UNSPSC Code:
41106213

Quality Level

description

shipped with cooling packs

product line

Cellvento®

form

dry powder

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | mammalian: suitable

greener alternative category

storage temp.

2-8°C

General description

Cellvento® ModiFeed Sial+ COMP is part of the ModiFeed platform. It is a highly concentrated, one-part, pH neutral feed added to replenish depleted nutrients required for cellular function and to extend the production phase in fed-batch mode, while simultanously maximizing sialylation on the protein of interest. It is recommended combination with the production media Cellvento® 4CHO and EX-CELL® Advanced CHO or other production media.
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Application

Control of protein glycosylation, such as sialylation, while maximizing productivity is key for successful therapeutic protein development and production. N-glycoslyations of IgG Fc, particularly sialylation, has been reported to exert significant anti-inflammatory effects. High sialylation levels can help to increase stability, safety, and efficacy of the protein of interest. Cellvento® ModiFeed Sial+ COMP was developed to increase sialylation while maintaining or improving titer in CHO fed-batch processes

Features and Benefits

  • Reduced complexity in fed-batch process
  • Complete feed maximizing galactosylation
  • Highly concentrated to reduce required feed volume
  • Compacted format for conventient handling
  • Higher liquid feed stability at room temperature

Quantity

Formulated to contain 155.8 grams of powder per liter of feed.

Legal Information

CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

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Articles

Cellvento® and EX-CELL® CHO cell culture media and feeds, optimized for monoclonal antibody & recombinant protein production in fed-batch & perfusion

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