12804
HBTU
≥98.0% (T), for peptide synthesis
동의어(들):
N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate, O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C11H16F6N5OP
CAS Number:
Molecular Weight:
379.24
Beilstein:
7328329
EC Number:
MDL number:
UNSPSC 코드:
12352107
PubChem Substance ID:
NACRES:
NA.22
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추천 제품
제품명
HBTU, ≥98.0% (T)
분석
≥98.0% (T)
양식
solid
반응 적합성
reaction type: Coupling Reactions
mp
200 °C (dec.) (lit.)
solubility
acetonitrile: 0.1 g/mL, clear
응용 분야
peptide synthesis
작용기
amine
저장 온도
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C
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일반 설명
HBTU is a peptide coupling agent used in Fmoc-based solid-phase peptide synthesis.[1]
애플리케이션
HBTU is a peptide coupling agent for peptide synthesis.[2] It has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol.[3]
Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Skin Sens. 1A
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
L P Miranda et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(4), 1181-1186 (1999-02-17)
The chemical synthesis of peptides and small proteins is a powerful complementary strategy to recombinant protein overexpression and is widely used in structural biology, immunology, protein engineering, and biomedical research. Despite considerable improvements in the fidelity of peptide chain assembly
The uronium/guanidinium peptide coupling reagents: finally the true uronium salts.
Carpino LA, et al.
Angewandte Chemie (International Edition in English), 41(3), 441-445 (2002)
Héloise Boullet et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Antimicrobial peptides (AMPs) are considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and alternative mechanisms of action compared to conventional antibiotics. Although AMPs present considerable advantages over conventional antibiotics, their clinical and commercial development still
Marc-Philipp Pfeil et al.
Scientific reports, 8(1), 14926-14926 (2018-10-10)
The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candidates in this regard. Here we demonstrate that
Mark Lommel et al.
Scientific reports, 8(1), 11753-11753 (2018-08-08)
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a
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