712191

COMU^®

≥96.5% (TLC), for peptide synthesis

• Synonym(s): (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
• Empirical Formula (Hill Notation): C₁₂H₁₉F₆N₄O₄P
• CAS Number: 1075198-30-9
• Molecular Weight: 428.27
• MDL number: MFCD11975052
• UNSPSC Code: 12352107
• PubChem Substance ID: 329763117
• NACRES: NA.22

Properties

• product name: COMU^®, 97%
• Quality Level: 100
• assay: ≥96.5% (TLC); 96.5-103.5% (T); 97%
• form: crystals
• reaction suitability: reaction type: Coupling Reactions
• greener alternative product characteristics: Less Hazardous Chemical Syntheses; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• application(s): peptide synthesis
• functional group: amine; ester; ether; nitrile
• greener alternative category: , Aligned
• storage temp.: 2-8°C
• SMILES string: F[P-](F)(F)(F)(F)F.CCOC(=O)C(=NO\C(N1CCOCC1)=[N+](/C)C)C#N
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• InChI key: GPDHNZNLPKYHCN-DZOOLQPHSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.

Application

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages

• Equal or even superior performance to HATU
• Non-explosive (does not contain benzotriazole moiety)
• Suitable for solution phase & solid phase peptide synthesis
• Utmost retention of configuration – low to non-existent racemization
• High solubility and stability in typical solvents
• Visual or colorimetric reaction monitoring possible
• Easy removal of water-soluble by-products

Morpholine-Based Immonium and Halogenoamidinium Salts as Coupling Reagents in Peptide Synthesis

Legal Information

COMU is a registered trademark of Luxembourg Bio Technologies Ltd.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves