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712191

Sigma-Aldrich

COMU®

greener alternative

97%

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Synonym(s):
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
Empirical Formula (Hill Notation):
C12H19F6N4O4P
CAS Number:
Molecular Weight:
428.27
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥96.5% (TLC)
96.5-103.5% (T)
97%

form

crystals

reaction suitability

reaction type: Coupling Reactions

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

application(s)

peptide synthesis

greener alternative category

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CCOC(=O)C(=NO\C(N1CCOCC1)=[N+](/C)C)C#N

InChI

1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI key

GPDHNZNLPKYHCN-DZOOLQPHSA-N

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This Item
6631318.5108563675
COMU® 97%

Sigma-Aldrich

712191

COMU®

RuPhos 98%

Sigma-Aldrich

663131

RuPhos

COMU 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®

Sigma-Aldrich

8.51085

COMU

(+)-Menthone analytical standard

Supelco

63675

(+)-Menthone

form

crystals

form

solid

form

powder

form

-

storage temp.

2-8°C

storage temp.

-

storage temp.

15-25°C

storage temp.

2-8°C

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Cross Couplings, reagent type: ligand
reaction type: Arylations, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: Negishi Coupling, reagent type: ligand
reaction type: Sonogashira Coupling, reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

reaction suitability

reaction type: Coupling Reactions

reaction suitability

-

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

Atom Economy
Design for Energy Efficiency
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

greener alternative product characteristics

-

greener alternative product characteristics

Atom Economy
Safer Solvents and Auxiliaries
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.

Application

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages
  • Equal or even superior performance to HATU
  • Non-explosive (does not contain benzotriazole moiety)
  • Suitable for solution phase & solid phase peptide synthesis
  • Utmost retention of configuration – low to non-existent racemization
  • High solubility and stability in typical solvents
  • Visual or colorimetric reaction monitoring possible
  • Easy removal of water-soluble by-products

Legal Information

COMU is a registered trademark of Luxembourg Bio Technologies Ltd.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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