추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
rat
제조업체/상표
Upstate®
기술
immunocytochemistry: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SYNGAP1(8831)
일반 설명
Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.
특이성
SynGAP
면역원
peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1289-1308 of rat SynGAP-a
애플리케이션
Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Synapse & Synaptic Biology
결합
Replaces: 04-1071
물리적 형태
Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol
저장 및 안정성
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
SynGAP isoforms exert opposing effects on synaptic strength.
McMahon, AC; Barnett, MW; O'Leary, TS; Stoney, PN; Collins, MO; Papadia, S; Choudhary et al.
Nature Communications null
Characterization of a novel synGAP isoform, synGAP-beta.
Li, W; Okano, A; Tian, QB; Nakayama, K; Furihata, T; Nawa, H; Suzuki, T
The Journal of Biological Chemistry null
Ayse Dosemeci et al.
FEBS letters, 590(17), 2934-2939 (2016-08-02)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B, also known as AIDA-1) is a major component of the postsynaptic density (PSD) in excitatory neurons where it concentrates at the electron-dense core under basal conditions and moves out during
Murat Kilinc et al.
eLife, 11 (2022-04-09)
Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellular functions of SynGAP proteins through coding of distinct C-terminal motifs.
Yuko Tanabe et al.
Nature communications, 8(1), 408-408 (2017-09-03)
Coordinated development of excitatory and inhibitory synapses is essential for higher brain function, and impairment in this development is associated with neuropsychiatric disorders. In contrast to the large body of accumulated evidence regarding excitatory synapse development, little is known about
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