추천 제품
생물학적 소스
Porcine kidney
Quality Level
형태
suspension (crystalline)
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
색상
white
solubility
physiological buffer: soluble
water: soluble
외래 활성
Oxidases ≤3%
배송 상태
ambient
저장 온도
2-8°C
관련 카테고리
일반 설명
Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.
애플리케이션
Aminopeptidase M, porcine kidney has been used:
- to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
- to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
- for the proteolysis of isolevuglandins (IsoLGs) proteins
생화학적/생리학적 작용
Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.
포장
Please refer to vial label for lot-specific concentration.
경고
Toxicity: Harmful (C)
단위 정의
One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.
물리적 형태
Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.
기타 정보
Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Handbook of Proteolytic Enzymes (2012)
James W Checco et al.
The Journal of biological chemistry, 293(43), 16862-16873 (2018-09-09)
l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides, peptide hormones, and peptide toxins from several animals. In most cases, the d-residue is critical for the biological function of the resulting d-amino acid-containing peptide (DAACP). Here, we
Oral Delivery of Peptide Formulations and Their Cellular Evaluation
Patil S, et al.
International Journal of Peptide Research and Therapeutics, 27(4), 2831-2844 (2021)
Valery N Yermalitsky et al.
Analytical biochemistry, 566, 89-101 (2018-11-21)
Isolevuglandins (IsoLGs) are a family of highly reactive 4-ketoaldehydes formed by lipid peroxidation that modify the lysyl residues of cellular proteins. Modification of proteins by IsoLGs have been shown to contribute to disease processes such as the development of hypertension.
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