추천 제품
생물학적 소스
mouse
Quality Level
클론
CC-1, monoclonal
양식
liquid
포함
≤0.1% sodium azide
종 반응성
human, mouse, rat
제조업체/상표
Calbiochem®
저장 조건
do not freeze
기술
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (frozen sections): suitable
dilution
(Free-floating SectionsParaffin Sections)
일반 설명
Recognizes APC in oligodendrocytes and astrocytes.
- Antibody Target Gene Symbol: APC
- Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC
- Entrez Gene Name: adenomatous polyposis coli
- Hu Entrez ID: 324 (Related Antibodies: ST1150, OP62, OP47L, OP44)
- Mu Entrez ID: 11789
- RatEntrez ID: 24205
면역원
a recombinant protein consisting of amino acids 1-226 of APC
애플리케이션
Frozen Sections (5 µg/ml) Immunofluorescence (5 µg/ml) Paraffin Sections (5 µg/ml, heat pre-treament required) Immunocytochemistry (see application references) Free Floating Sections (see application references)
Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody′s staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.
Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody′s staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.
포장
Please refer to vial label for lot-specific concentration
경고
Toxicity: Standard Handling
물리적 형태
In 50 mM sodium phosphate buffer, 0.2% gelatin.
분석 메모
Negative control: MOPC 21 cells
Positive control: Purkinje cells or cerebellum tissue
Positive control: Purkinje cells or cerebellum tissue
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
J Groden et al.
Cell, 66(3), 589-600 (1991-08-09)
DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients. The intron-exon boundary sequences were defined for
L K Su et al.
Cancer research, 53(12), 2728-2731 (1993-06-15)
Germline mutations of the APC gene are responsible for familial adenomatous polyposis, an autosomal dominant inherited predisposition to colorectal tumors. Mutation of the APC gene is also an early, if not initiating, event for sporadic colorectal tumorigenesis. In both cases
K J Smith et al.
Cancer research, 54(14), 3672-3675 (1994-07-15)
The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant
L K Su et al.
Science (New York, N.Y.), 262(5140), 1734-1737 (1993-12-10)
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
Bhat, R.V., et al.
The Journal of Neuroscience, 14, 3059-3071 (1994)
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