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![trans-4-[4-(Dimethylamino)styryl]-1-methylpyridinium iodide Dye content 98 %](/deepweb/assets/sigmaaldrich/product/structures/416/722/5d59b6c3-5f2d-4396-a721-5cb82ba7038c/640/5d59b6c3-5f2d-4396-a721-5cb82ba7038c.png)
양식
powder
Quality Level
구성
Dye content, ~90%
기술
titration: suitable
mp
270 °C (dec.) (lit.)
λmax
512 nm
응용 분야
diagnostic assay manufacturing
hematology
histology
저장 온도
room temp
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45
InChI
1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
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일반 설명
Thiazole Orange can be tethered with peptide nucleic acid for the detection of target nucleic acid in homogeneous solution.[1] It is a dye with, both predicted physical characteristics and the biological staining characteristics of a good reticulocyte dye, hence it is considered as a dye for reticulocyte analysis. It has massive fluorescence enhancement and high quantum yield upon binding to nucleic acids, particularly RNA. It is non precipitating and can permeates through live cell membranes.[2]
애플리케이션
Thiazole orange has been used for the staining and thereby quantification of reticulocytes.[3]
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
Adam D Cawte et al.
Nature communications, 11(1), 1283-1283 (2020-03-11)
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism. RNA aptamers, such as Spinach and Mango, have recently emerged as a powerful
Danitza Nébor et al.
Scientific reports, 8(1), 12793-12793 (2018-08-26)
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Adams AB
Journal of Immunology, 167(2), 1103-1111 (2001)
Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution.
Svanvik N
Analytical Biochemistry, 281(1), 26-35 (2000)
L G Lee et al.
Cytometry, 7(6), 508-517 (1986-11-01)
The purpose of this study was to find a 488-nm excitable fluorescent dye for reticulocyte analysis by the use of fluorescence activated cell cytometry. The chemical structure of thioflavin T, a dye used for reticulocyte analysis with 457-nm excitation, was
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