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T3516

Sigma-Aldrich

Thioflavin T

used as stain for amyloid

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Synonym(s):
Basic Yellow 1, Thioflavine T
Empirical Formula (Hill Notation):
C17H19ClN2S
CAS Number:
Molecular Weight:
318.86
Colour Index Number:
49005
Beilstein/REAXYS Number:
3922452
EC Number:
MDL number:
PubChem Substance ID:

form

powder

composition

Dye content, ≥65%

solubility

methanol: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

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1 of 4

This Item
T1892F6377R6626
vibrant-m

T3516

Thioflavin T

vibrant-m

T1892

Thioflavine S

vibrant-m

F6377

Fluorescein sodium salt

vibrant-m

R6626

Rhodamine B

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

solubility

methanol: 1 mg/mL

solubility

ethanol: water (1:1): 1 mg/mL

solubility

H2O: 1 mg/mL

solubility

H2O: 1 mg/mL

General description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Application

Thioflavin T has been used to identify the presence of amyloid fibrils in samples.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 5

1 of 5

Pai Peng et al.
Nucleic acids research, 45(2), 541-546 (2016-12-03)
We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.
Extrinsic fluorescent dyes as tools for protein characterization.
Hawe, A., et al.
Pharmaceut. Res., 25, 1487-1499 (2008)
Ritu Khurana et al.
Journal of structural biology, 151(3), 229-238 (2005-08-30)
Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles
Matthew Biancalana et al.
Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
Jian Xiong et al.
Biophysical chemistry, 220, 42-48 (2016-11-20)
The hydrophobic fragment of the Alzheimer's related β-amyloid (Aβ) peptide, Aβ(25-40), aggregates and forms insoluble amyloid fibrils at a rate similar to the full-length peptide. In order to gain insight into the fibrillization of Aβ(25-40) and the ability of the

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