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596200

Sigma-Aldrich

Thioflavin T

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils.

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Synonym(s):
Thioflavin T, ThT, Thioflavine T, Basic Yellow 1
Empirical Formula (Hill Notation):
C17H19ClN2S
CAS Number:
Molecular Weight:
318.86
MDL number:

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

water: 5 mg/mL

fluorescence

λex ~385 nm (free)
λex ~437 nm
λem ~445 nm (free)
λem ~485 nm

shipped in

ambient

storage temp.

15-25°C

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

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This Item
T3516T1892T0175
Thioflavin T A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils.

596200

Thioflavin T

Thioflavin T used as stain for amyloid

T3516

Thioflavin T

Thioflavine S practical grade

T1892

Thioflavine S

Sigma-Aldrich

T0175

Troponin T from human heart

color

yellow

color

-

color

light beige to dark beige, to Dark Brown

color

-

form

solid

form

powder

form

powder

form

lyophilized powder

solubility

water: 5 mg/mL

solubility

methanol: 1 mg/mL

solubility

ethanol: water (1:1): 1 mg/mL

solubility

10 mM HCl: 500 μg/mL, clear, colorless

storage temp.

15-25°C

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

shipped in

ambient

shipped in

-

shipped in

-

shipped in

dry ice

General description

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates.
A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates. Associates with aggregated fibrils of synthetic β/A4-derived peptides β(1-28) and β(1-40), resulting in a shift in the excitation maximum and an enhanced emission. Excitation max.: ~385 nm (free); ~437 nm (bound); emission max.: ~445 nm (free); ~485 nm (bound).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Exhibits enhanced fluorescence upon binding to amyloid fibrils
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tjernberg, L.O., et al. 1999. J. Biol. Chem.274, 12619.
Naiki, H. and Nakakuki, K. 1996. Lab. Invest.74, 374.
LeVine, H. 1993. Protein Sci.2, 404.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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