A2487

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

• 동의어(들): Trimethoprim-Sulfamethoxazole, TMP-SMX
• 실험식(Hill 표기법): C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• CAS Number: 8064-90-2
• Molecular Weight: 1556.71
• UNSPSC 코드: 51102829
• NACRES: NA.85

속성

• 형태: liquid
• Quality Level: 200
• 농도: 100 mg/mL in DMSO
• 색상: colorless to faint yellow
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• 동작 모드: DNA synthesis | interferes
• 배송 상태: dry ice
• 저장 온도: −20°C
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• InChI key: WZRJTRPJURQBRM-UHFFFAOYSA-N

설명

애플리케이션

Cotrimoxazole has been used as an antimicrobial agent.

생화학적/생리학적 작용

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

포장

1ml

제조 메모

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361fd,H412
• 예방조치 성명서: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 2
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable