A4529

Aprotinin

3-7 TIU/mg solid, lyophilized powder

• 동의어(들): BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)
• 실험식(Hill 표기법): C₂₈₄H₄₃₂N₈₄O₇₉S₇
• CAS Number: 9087-70-1
• Molecular Weight: 6511.44
• EC Number: 232-994-9
• MDL number: MFCD00130541
• UNSPSC 코드: 12352202
• NACRES: NA.54

속성

• 제품명: Aprotinin from bovine lung, lyophilized powder, 3-7 TIU/mg solid
• 생물학적 소스: bovine lung
• 양식: lyophilized powder
• 특이 활성도: 3-7 TIU/mg solid
• 분자량: ~6,500
• solubility: H₂O: >10 mg/mL
• UniProt 수납 번호: P00974
• 저장 온도: 2-8°C
• SMILES string: S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O
• InChI key: ZPNFWUPYTFPOJU-UHFFFAOYSA-N
• 유전자 정보: cow ... PTI(404172)

설명

애플리케이션

Aprotinin is largely used as an inhibitor of trypsin.

생화학적/생리학적 작용

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

단위 정의

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

제조 메모

This product is an affinity purified lyophilized powder purified to remove trace impurities. It has an activity of 3-7 TIU/mg.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)