A7127

Agmatine sulfate salt

≥97% (TLC), powder, ion channel blocker

• 동의어(들): 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt
• Linear Formula: H₂N(CH₂)₄NHC(=NH)NH₂·H₂SO₄
• CAS Number: 2482-00-0
• Molecular Weight: 228.27
• Beilstein: 3918807
• EC Number: 219-617-3
• MDL number: MFCD00013109
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277749
• NACRES: NA.32

속성

• product name: Agmatine sulfate salt, ≥97%, powder
• Quality Level: 100
• 분석: ≥97%
• 형태: powder
• 색상: white to off-white
• mp: 234-238 °C (lit.)
• solubility: H₂O: 50 mg/mL; ethanol: insoluble
• SMILES string: OS(O)(=O)=O.NCCCCNC(N)=N
• InChI: 1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
• InChI key: PTAYFGHRDOMJGC-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

설명

애플리케이션

Agmatine sulfate salt has been used:

• to study its effects on nod-like receptor protein 3 (NLRP3) inflammasome activation and cytokine responses in sub-chronic restraint stress rat models
• as an N-methyl-D-aspartate (NMDA) receptor blocker to study its therapeutic effects on autistic behaviors in the valproic acid-induced animal model of autism
• as a standard to determine the bioactive amines in vegetables by high-performance liquid chromatography (HPLC)

생화학적/생리학적 작용

Agmatine is a decarboxylated arginine that is present ubiquitously in all living organisms. It is found in food sources such as plant source food and animal products. It exhibits cryoprotective effects against several body functions such as nephroprotection, neuroprotection, gastroprotection, and cardioprotection. Agmatine also exhibits therapeutic effects against neurotrauma, neuropathic pain, diabetes, neurodegenerative diseases, and psychiatric diseases. It is involved in blocking many ionic channels such as ATP-sensitive K⁺ channels and voltage-gated Ca²⁺ channels. Agmatine modulates nitric oxide production and inhibits matrix metalloproteases.

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α₂-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)