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S2626

Sigma-Aldrich

Spermidine

≥99% (GC)

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Synonym(s):
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
Molecular Weight:
145.25
Beilstein/REAXYS Number:
1698591
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic

Quality Level

assay

≥99% (GC)

form

solid or liquid (clear)

impurities

DNase, none detected
RNase, none detected
protease, none detected

refractive index

n20/D 1.479 (lit.)

mp

22-25 °C

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

density

0.925 g/mL at 25 °C (lit.)

storage temp.

room temp

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Gene Information

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This Item
85558S0266S2501
Spermidine ≥99% (GC)

S2626

Spermidine

-
Spermidine BioUltra, for molecular biology, ≥99.5% (GC)

85558

Spermidine

Premium Grade
Spermidine BioReagent, for molecular biology, suitable for cell culture, ≥98%

S0266

Spermidine

Essential+ Grade
Spermidine trihydrochloride ≥98% (TLC)

S2501

Spermidine trihydrochloride

-
biological source

synthetic

biological source

-

biological source

-

biological source

microbial, synthetic

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid or liquid (clear)

form

-

form

solid or liquid

form

powder

Gene Information

rat ... Ppm1a(24666)

Gene Information

rat ... Ppm1a(24666)

Gene Information

rat ... Ppm1a(24666)

Gene Information

human ... NOS1(4842)

impurities

DNase, none detected, protease, none detected, RNase, none detected

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

impurities

-

impurities

-

General description

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.

Application

Spermidine has been used:
  • in the preparation of 5x transcription buffer
  • in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
  • as a standard in the analytical study of rat brain polyamines (185)

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Other Notes

Store under inert gas. Air sensitive; strongly hygroscopic.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Protocols

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

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