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S1141

Sigma-Aldrich

Spermine tetrahydrochloride

BioReagent, for molecular biology

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Synonym(s):
N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Empirical Formula (Hill Notation):
C10H26N4 · 4HCl
CAS Number:
Molecular Weight:
348.18
Beilstein/REAXYS Number:
3911771
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.52

grade

for molecular biology

Quality Level

product line

BioReagent

form

solid

mp

310-311 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

foreign activity

DNase, RNase, protease, NICKase, none detected

storage temp.

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

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This Item
85605856105677
Spermine tetrahydrochloride BioReagent, for molecular biology

S1141

Spermine tetrahydrochloride

Essential+ Grade
Spermine tetrahydrochloride BioUltra, for molecular biology, ≥99.5% (AT)

85605

Spermine tetrahydrochloride

Premium Grade
Spermine tetrahydrochloride ≥99.0% (AT), powder or crystals

85610

Spermine tetrahydrochloride

-
Spermine, Tetrahydrochloride

5677

Spermine, Tetrahydrochloride

-
Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

10-30°C

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

solubility

H2O: 1 m at 20 °C, clear, colorless to almost colorless

solubility

H2O: 0.1 g/mL, clear

solubility

water: 20 mg/mL

grade

for molecular biology

grade

for molecular biology

grade

-

grade

-

product line

BioReagent

product line

BioUltra

product line

-

product line

-

General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

related product

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
D C Allison et al.
Annals of surgery, 214(6), 648-656 (1991-12-01)
The DNA content of 47 adenocarcinomas arising in the head of the pancreas from patients who had undergone successful pancreatoduodenectomy was measured. The DNA measurements of each tumor were made without knowledge of the clinical course by absorption cytometry performed

Protocols

This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases.

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