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P7505

Sigma-Aldrich

Putrescine dihydrochloride

≥98% (TLC)

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Synonym(s):
1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
Molecular Weight:
161.07
Beilstein/REAXYS Number:
3906680
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

≥98% (TLC)

form

powder

mp

280 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless

SMILES string

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

InChI key

XXWCODXIQWIHQN-UHFFFAOYSA-N

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This Item
P6024P578032810
Putrescine dihydrochloride ≥98% (TLC)

P7505

Putrescine dihydrochloride

Putrescine dihydrochloride γ-irradiated, lyophilized powder, BioXtra, suitable for cell culture

P6024

Putrescine dihydrochloride

Putrescine dihydrochloride powder, BioReagent, suitable for cell culture

P5780

Putrescine dihydrochloride

1,4-Diaminobutane dihydrochloride purum, ≥99.0% (AT)

32810

1,4-Diaminobutane dihydrochloride

form

powder

form

lyophilized powder

form

powder

form

powder

Quality Level

400

Quality Level

200

Quality Level

200

Quality Level

400

solubility

H2O: soluble 100 mg/mL, clear, colorless

solubility

cell culture medium: 0.16 mg/mL

solubility

H2O: 100 mg/mL

solubility

water: soluble 1 g/10 mL, clear, colorless

mp

280 °C (dec.) (lit.)

mp

280 °C (dec.) (lit.)

mp

280 °C (dec.) (lit.)

mp

280 °C (dec.) (lit.)

Application

Putrescine dihydrochloride has been used:
  • as a bioactive amine standard in high-performance liquid chromatography (HPLC)
  • as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
  • as a supplement in DMEM for culturing of endometrial cancer cells

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.

pictograms

CorrosionSkull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Ulises Gómez-Pinedo et al.
Frontiers in neurology, 8, 255-255 (2017-06-22)
Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect
Zhi-Gang Qian et al.
Biotechnology and bioengineering, 104(4), 651-662 (2009-08-29)
A four carbon linear chain diamine, putrescine (1,4-diaminobutane), is an important platform chemical having a wide range of applications in chemical industry. Biotechnological production of putrescine from renewable feedstock is a promising alternative to the chemical synthesis that originates from
Vegetables consumed in Brazilian cuisine as sources of bioactive amines
Dala-Paula B M, et al.
Food Bioscience, 40, 100856-100856 (2021)
Mito Kanatsu-Shinohara et al.
Methods in enzymology, 477, 17-36 (2010-08-12)
Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem
Bangmin Liu et al.
Journal of animal science and biotechnology, 10, 69-69 (2019-09-14)
Polyamines are essential for cell growth and beneficial for intestinal maturation. To evaluate the effects of putrescine on alleviating intestinal atrophy and underlying molecular mechanisms, both in vivo feeding trial and in vitro cell culture were conducted. Weanling pigs were

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