B5936

Brefeldin A

from Penicillium brefeldianum, Ready Made Solution, 10 mg/mL in DMSO

• 동의어(들): Synergisidin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
• 실험식(Hill 표기법): C₁₆H₂₄O₄
• CAS Number: 20350-15-6
• Molecular Weight: 280.36
• Beilstein: 25191
• MDL number: MFCD12913297
• UNSPSC 코드: 51102829
• PubChem Substance ID: 329773270
• NACRES: NA.85

속성

• 생물학적 소스: Penicillium brefeldianum
• Quality Level: 200
• vapor pressure: 0.56 hPa ( 20 °C)
• 양식: solution
• autoignition temp.: 301 °C
• 농도: 10 mg/mL in DMSO
• solubility: DMSO: 10 mg/mL
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: cell membrane | interferes
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• SMILES string: C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
• InChI: 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
• InChI key: KQNZDYYTLMIZCT-KQPMLPITSA-N

설명

애플리케이션

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.

생화학적/생리학적 작용

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Hygroscopic.Storage class (TRGS 510): Combustible liquids

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup
• Flash Point (°C): 87 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)