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I0634

Sigma-Aldrich

Ionomycin calcium salt from Streptomyces conglobatus

powder, ≥98% (HPLC)

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Synonym(s):
SQ23377 calcium
Empirical Formula (Hill Notation):
C41H70CaO9
CAS Number:
Molecular Weight:
747.07
Beilstein:
1416163
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

white to off-white

solubility

DMSO: 10 mg/mL
ethanol: soluble

antibiotic activity spectrum

Gram-positive bacteria

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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Show Differences

1 of 4

This Item
407950SML0234SML1380
Mitiglinide calcium ≥98% (HPLC)

Sigma-Aldrich

SML0234

Mitiglinide calcium

form

powder

form

waxy solid

form

powder

form

powder

storage condition

desiccated, protect from light

storage condition

OK to freeze, protect from light

storage condition

desiccated

storage condition

desiccated

color

white to off-white

color

-

color

white to beige

color

white to beige

solubility

DMSO: 10 mg/mL, ethanol: soluble

solubility

DMSO: 10 mg/mL, methanol: 10 mg/mL

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

Application

Ionomycin calcium salt from Streptomyces conglobatus has been used as a media supplement to culture:

  • peripheral blood mononuclear cells (PBMCs) for immunologic assessment
  • oocytes for parthenogenetic activation
  • T cell subsets for the detection of intracellular cytokines, carboxyfluorescein diacetate succinimidyl ester (CFSE) proliferation assay, and antigen-specific suppressive function assay
  • in combination with phorbol12-myristate 13-acetate (PMA) to stimulate T-cell activation in various cells
  • as sperm capacitation medium supplement to study its impact on in vitro fertilization and increasing the efficiency of bovine embryo development
  • as a positive control for the detection of intracellular Ca2+ in adipose-derived stem cells (ASCs)(4)

Biochem/physiol Actions

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is an ionophore, widely used for validation and calibration of calcium analysis.

Preparation Note

Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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