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Merck
모든 사진(1)

주요 문서

E5630

Sigma-Aldrich

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA

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모든 사진(1)

About This Item

MDL number:
MFCD03613560
UNSPSC 코드:
51111800
NACRES:
NA.77
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무균

non-sterile

Quality Level

200

양식

lyophilized powder

라벨링 범위

~30 mol steroid per mol BSA

solubility

phosphate buffer: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

배송 상태

ambient

저장 온도

2-8°C

관련 카테고리

일반 설명

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA is an estradiol conjugate and is membrane-impermeable.[1] BSA is linked to the estradiol at position 6 to form the β-estradiol 6-(O-carboxymethyl) oxime: BSA conjugate.[1]

애플리케이션

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA has been used:
  • to test its effect on the N-methyl-D-aspartate receptor (NMDAR) currents in female dorsal root ganglion (DRG) neurons[2]
  • to coat microplates for the detection of plasma 17β-Estradiol levels using indirect enzyme-linked immunosorbent assay (ELISA)[3]
  • to test its effect on MutL homolog 1 in colorectal cancer lines[4]

생화학적/생리학적 작용

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA mimics estrogen and favors amyloid precursor protein α (sAPPα) secretion in vitro studies with primary rat cortical neurons.[1] It also stimulates mitogen-activated protein kinase (MAPK) activity in human umbilical vein endothelial cells [5]

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Warning

유해 및 위험 성명서

H302 + H312 + H332,H351

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number
0000434312
0000434311
0000434312
0000434311
0000145806

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Adrián Tintos et al.
Ecotoxicology and environmental safety, 66(2), 139-147 (2006-02-10)
To assess the effects of naphthalene on liver intermediary metabolism and plasma steroid hormones, immature female rainbow trout (Oncorhynchus mykiss), in a first experiment, were intraperitoneally injected (2 microLg(-1)) with vegetable oil alone (control) or containing naphthalene (10 and 50
Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons.
McRoberts, et al.
Neuroscience, 148, 1015-1020 (2018)
Sun Zhang et al.
Acta pharmacologica Sinica, 26(2), 171-176 (2005-01-25)
To investigate the mechanism of the action of estrogen, which stimulates the release of secreted amyloid precursor protein alpha (sAPP(alpha)) and decreases the generation of amyloid-beta protein (A(beta)), a dominant component in senile plaques in the brains of Alzheimer's disease
K S Russell et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(11), 5930-5935 (2000-05-24)
Estrogen induces both rapid and delayed effects on the cardiovascular system. The early effects take place within minutes (e.g., changes in vasomotor tone) and are mediated through rapid intracellular signaling pathways; whereas the delayed effects (e.g., remodeling or lipid alterations)
Claudio R F Marinho et al.
PloS one, 4(5), e5630-e5630 (2009-05-23)
Pregnancy-associated malaria (PAM) is associated with placenta pathology and poor pregnancy outcome but the mechanisms that control the malaria parasite expansion in pregnancy are still poorly understood and not amenable for study in human subjects. Here, we used a set
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