G9793

N-Glycolylneuraminic acid

≥95% (HPLC), semisynthetic

• 동의어(들): Neu5Glc, NeuNGl
• 실험식(Hill 표기법): C₁₁H₁₉NO₁₀
• CAS Number: 1113-83-3
• Molecular Weight: 325.27
• Beilstein: 1716828
• MDL number: MFCD00057551
• UNSPSC 코드: 12352201
• PubChem Substance ID: 24895382
• NACRES: NA.25

속성

• 생물학적 소스: semisynthetic
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• 기술: LC/MS: suitable
• 불순물: water (Karl Fischer)
• 색상: white
• solubility: water: soluble 20 mg/mL
• 적합성: suitable for LC-MS
• 응용 분야: metabolomics
• 저장 온도: −20°C
• SMILES string: [H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O)[C@H](O)[C@H](O)CO
• InChI: 1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1
• InChI key: FDJKUWYYUZCUJX-AJKRCSPLSA-N

설명

일반 설명

N-Glycolylneuraminic acid (Neu5Gc) is a nonhuman sialic acid molecule synthesized in pigs but not in humans, that has a role as a mammalian metabolite and an antigen. This hydroxylated form of sialic acid, specifically N-acetylneuraminic acid, features a glycolyl substituent on nitrogen and a beta-configuration at the anomeric center. The biosynthesis of N-glycolylneuraminic acid involves the enzymatic activity of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase.
In humans, the absence of endogenous production results from a gene mutation affecting CMP-Neu5Ac hydroxylase, the enzyme responsible for converting N-acetylneuraminic acid into Neu5Gc. However, Neu5Gc can accumulate in human cells through external ingestion from dietary sources like red meat and dairy products. N-Glycolylneuraminic acid is a versatile compound that finds application in cell biology, metabolomics and biochemical research

애플리케이션

N-Glycolylneuraminic acid has been used:

• as a sugar in microtiter biofilm methodologic approach for the enhancement of biofilm formation
• as a standard for the determination of sialic acids in the nervous system of silkworm and to find the variations of sialic acids among different developmental stages.
• as a standard in the high-performance liquid chromatography (HPLC) analyses to detect the molecular species of sialic acid (Sia) species using 1,2-diamino-4,5-methylenedioxy-benzene (DMB) as a fluorogenic compound

생화학적/생리학적 작용

N-Glycolylneuraminic acid (Neu5Gc) functions as an important tool for profiling anti-Neu5Gc antibodies and sialic acid-binding proteins.

특징 및 장점

• Ideal for Metabolomics, Biochemical and Cell Biology research
• Versatile and adaptable for wide variety of laboratory and research applications

기타 정보

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)