M1787

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.:room temp

• 동의어(들): Manganese chlroide, Manganese(II) chloride, MnCl₂
• Linear Formula: MnCl₂
• CAS Number: 7773-01-5
• Molecular Weight: 125.84
• MDL number: MFCD00011114
• UNSPSC 코드: 12352302
• PubChem Substance ID: 24896693
• NACRES: NA.52

속성

• Grade: for molecular biology
• Quality Level: 200
• 무균: 0.2 μm filtered
• 제품 라인: BioReagent
• 형태: liquid
• 농도: 1.00 M±0.01 M
• 양이온 미량물: heavy metals (as Pb): ≤5 ppm
• 외래 활성: DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
• 저장 온도: room temp
• SMILES string: Cl[Mn]Cl
• InChI: 1S/2ClH.Mn/h2*1H;/q;;+2/p-2
• InChI key: GLFNIEUTAYBVOC-UHFFFAOYSA-L

설명

일반 설명

Manganese (II) chloride (MnCl₂) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl₂ has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl₂ solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn₂⁺ can be substituted for Mg₂⁺ as a divalent metal ion to facilitate DNase I activity in presence of Ca₂⁺.

애플리케이션

Manganese (II) chloride solution has been used:

• in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
• in high ionic strength reaction mixture to determine RNA polymerase I and II activity
• in reverse transcription reaction mix as a source of Mn₂⁺ ions

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H318,H373
• 예방조치 성명서: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• 표적 기관: Brain
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)