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M5005

Sigma-Aldrich

Manganese(II) chloride tetrahydrate

BioReagent, suitable for insect cell culture

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Synonym(s):
Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O
Linear Formula:
MnCl2 · 4H2O
CAS Number:
Molecular Weight:
197.91
EC Number:
MDL number:
PubChem Substance ID:

product line

BioReagent

Assay

≥99% (by AgNO3, titration)

technique(s)

cell culture | insect: suitable

mp

58 °C (lit.)

SMILES string

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

InChI key

CNFDGXZLMLFIJV-UHFFFAOYSA-L

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This Item
63535M80541.05927
Manganese(II) chloride tetrahydrate BioReagent, suitable for insect cell culture

Sigma-Aldrich

M5005

Manganese(II) chloride tetrahydrate

Essential+ Grade
Manganese(II) chloride tetrahydrate BioUltra, for molecular biology, ≥99.0% (KT)

Sigma-Aldrich

63535

Manganese(II) chloride tetrahydrate

Premium Grade
mp

58 °C (lit.)

mp

58 °C (lit.)

mp

58 °C (lit.)

mp

650 °C (anhydrous substance)

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

product line

BioReagent

product line

BioUltra

product line

-

product line

EMSURE®

technique(s)

cell culture | insect: suitable

technique(s)

-

technique(s)

-

technique(s)

-

redoxing cation, enzyme cofactor

-

-

-

Application

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium
  • as a supplement in the culture medium for cochlear organotypic culture
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice

Biochem/physiol Actions

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

Target Organs

Brain

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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Customers Also Viewed

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Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)

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