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Merck
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주요 문서

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M3324

Sigma-Aldrich

M100907

≥98% (HPLC)

동의어(들):

(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol, MDL100907, Volinanserin

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About This Item

실험식(Hill 표기법):
C22H28FNO3
CAS Number:
139290-65-6
Molecular Weight:
373.46
MDL number:
MFCD00909060
UNSPSC 코드:
12352200
PubChem Substance ID:
329817971
NACRES:
NA.77
가격 및 재고 정보를 현재 이용할 수 없음

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

off-white to light brown

solubility

DMSO: ≥20 mg/mL

저장 온도

2-8°C

SMILES string

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChI key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

유전자 정보

human ... HTR2A(3356)

일반 설명

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects.[1] It may be used for treating dopaminergic anomalies.[2]

생화학적/생리학적 작용

M100907 is a selective 5-HT2A Antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000231275
0000231275
0000163486
0000163487
0000163486

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문서 라이브러리 방문

Ragy R Girgis et al.
Psychiatry research, 194(3), 230-234 (2011-11-15)
Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin
Paul J Fletcher et al.
Neuropharmacology, 62(7), 2288-2298 (2012-02-22)
The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor
Kathryn A Cunningham et al.
ACS chemical neuroscience, 4(1), 110-121 (2013-01-22)
Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote
The selective 5-HT 2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine
Marek GJ, et al.
Neuropsychopharmacology, 30(12), 2205-2205 (2005)
Meaghan Creed-Carson et al.
Behavioural brain research, 219(2), 273-279 (2011-01-26)
An important limitation of classical antipsychotic drugs such as haloperidol (HAL) is their liability to induce extrapyramidal motor symptoms acutely and tardive dyskinetic syndromes when given chronically. These effects are less likely to occur with newer antipsychotic drugs, an attribute
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