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G5918

Sigma-Aldrich

GR 113808

≥98% (HPLC), solid

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Synonym(s):
1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate
Empirical Formula (Hill Notation):
C19H27N3O4S
CAS Number:
Molecular Weight:
393.50
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

white to light pink

solubility

DMSO: >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChI key

MOZPSIXKYJUTKI-UHFFFAOYSA-N

Gene Information

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GR 113808 ≥98% (HPLC), solid

G5918

GR 113808

SPD304 ≥98% (HPLC), solid

S1697

SPD304

Sigma-Aldrich

SML1280

TT01001

Sigma-Aldrich

SML1217

TG4-155

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >20 mg/mL

solubility

H2O: >5 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to light pink

color

white

color

white to beige

color

white to beige

originator

GlaxoSmithKline

originator

-

originator

-

originator

-

Application

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Biochem/physiol Actions

GR 113808 is a 5-HT4 serotonin receptor antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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