M9066

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), male

• 동의어(들): Liver microsome preparation
• UNSPSC 코드: 12161501
• NACRES: NA.47

속성

• 생물학적 소스: rat (Sprague-Dawley)
• Quality Level: 200
• 양식: liquid
• 포장: vial of ~10 mg
• 배송 상태: dry ice
• 저장 온도: −70°C

설명

일반 설명

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]

애플리케이션

Microsomes from Liver, Pooled has been used in following studies:

• inhibition of microsomal lipid peroxidation.[2]
• hydroxylation of isorhynchophylline (ISOR) in rats.[3]

생화학적/생리학적 작용

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[4] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.[3]

Source of drug metabolizing enzymes, including cytochrome P-450.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable