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H5042

Sigma-Aldrich

Cytochrome P450 3A4 human

recombinant, expressed in E. coli

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Synonym(s):
Cytochrome P450, purified, soluble, CYP3A4
CAS Number:
NACRES:
NA.54

biological source

human

Quality Level

recombinant

expressed in E. coli

description

purified, soluble

form

liquid

specific activity

12-200 units/mg protein

mol wt

57318.7 g/mol

concentration

3.5-25 mg protein/mL (protein)
50-150 nmol/mL (P450)
6-14 nmol/mg protein (specific content)

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CYP3A4(1576)

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This Item
H5292MTOXCE3A4MTOXCE1A2
Sigma-Aldrich

H5042

Cytochrome P450 3A4 human

Sigma-Aldrich

H5292

Cytochrome P450 2C19 I331V, human

biological source

human

biological source

human

biological source

human

biological source

human

concentration

3.5-25 mg protein/mL (protein), 6-14 nmol/mg protein (specific content), 50-150 nmol/mL (P450)

concentration

3.2-25 mg protein/mL (protein), 50-150 nmol/mL (P450), 6-14 nmol/mg protein (specific content)

concentration

-

concentration

-

form

liquid

form

liquid

form

dry powder

form

dry powder

mol wt

57318.7 g/mol

mol wt

54783.3 g/mol

mol wt

-

mol wt

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

Supplied as purified soluble proteins, rather than microsomal preparations.

Application

Cytochrome P450 3A4 human has been used in circular dichroism analysis.

Biochem/physiol Actions

Cytochrome P450 3A4 (CYP3A4) is one of the isoform of cytochrome P450 (P450s). Cytochrome P450s (P450s) play a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.

Unit Definition

One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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25G
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Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
Zhang Y, et al.
Advances in Functional Materials, 26(6), 841-850 (2016)
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
Dresser, et al.
Clinical Pharmacokinetics, 38(1), 41-57 (2000)
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
Williams PA, et al.
Science, 305(5684), 683-686 (2004)
Yicong Bian et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1336-1340 (2015-06-14)
Minipigs represent a good animal model because of the physiologic and anatomic similarities they share with humans. Three cytochrome P450 (CYP) 3A isozymes, CYP3A22, CYP3A29, and CYP3A46, have recently been reported to be expressed in Bama minipigs, which have limited
Haifeng Zhang et al.
PloS one, 10(6), e0128547-e0128547 (2015-06-06)
Human cytochrome b5 (Cyt b5) plays important roles in cytochrome P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt b5 in normal human liver remains largely unknown. The effect of Cyt b5 on overall CYP activity in human liver

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