추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
rat, human
기술
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... KCNN3(3782)
rat ... Kcnn3(54263)
일반 설명
The calcium-activated potassium ion channel (KCNN3) is a voltage-independent small-conductance calcium-activated potassium channel. It is abundantly expressed in the brain and central nervous system. Its predominant expression is seen in the hypothalamus. KCNN3 gene is located on human chromosome 1q21.3.
면역원
synthetic peptide corresponding to amino acids 2-21 of human potassium channel SK3. The epitope is highly homologous in rat.
애플리케이션
Anti-Potassium Channel SK3 (KCa3, KCNN3, SKCa3) antibody produced in rabbit has been used in western blot analysis (1:250) and immunohistochemical staining (1:50).
생화학적/생리학적 작용
Anti-Potassium channel SK3 recognizes the SK3 protein in humans and rats by immunoblotting. Potassium channels contribute to maintaining cell volume, membrane potential, neuronal excitability, and the secretion of transmitters, salt, and hormones. It is extremely sensitive to changes in intracellular calcium levels, which are common during action potentials. KCNN3 helps to determine neuronal firing rates via the after-hyperpolarization. It is a migraine candidate susceptibility gene. Aberrations in the KCNN3 gene may trigger cortical spreading depression (CSD) and trigeminal sensitivity.
물리적 형태
Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
가장 최신 버전 중 하나를 선택하세요:
Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases.
Aurélie Chantôme et al.
Cancer research, 73(15), 4852-4861 (2013-06-19)
The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown
Hannah C Cox et al.
The journal of headache and pain, 12(6), 603-608 (2011-10-28)
The calcium-activated potassium ion channel gene (KCNN3) is located in the vicinity of the familial hemiplegic migraine type 2 locus on chromosome 1q21.3. This gene is expressed in the central nervous system and plays a role in neural excitability. Previous
Dieniffer Peixoto-Neves et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(31), e2303238120-e2303238120 (2023-07-26)
Endothelial cells (ECs) line the lumen of all blood vessels and regulate functions, including contractility. Physiological stimuli, such as acetylcholine (ACh) and intravascular flow, activate transient receptor potential vanilloid 4 (TRPV4) channels, which stimulate small (SK3)- and intermediate (IK)-conductance Ca2+-activated
Maxime Guéguinou et al.
Oncotarget, 7(24), 36168-36184 (2016-04-23)
Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized that this could depends on their efficiency to reduce Store Operated Calcium Entry (SOCE) that are known
Charles E MacKay et al.
eLife, 11 (2022-03-02)
Polycystin-1 (PC-1, PKD1), a receptor-like protein expressed by the Pkd1 gene, is present in a wide variety of cell types, but its cellular location, signaling mechanisms, and physiological functions are poorly understood. Here, by studying tamoxifen-inducible, endothelial cell (EC)-specific Pkd1
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