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Merck
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S1141

Sigma-Aldrich

Spermine tetrahydrochloride

BioReagent, for molecular biology

동의어(들):

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C10H26N4 · 4HCl
CAS Number:
306-67-2
Molecular Weight:
348.18
Beilstein:
3911771
EC Number:
206-189-8
MDL number:
MFCD00012914
UNSPSC 코드:
12352116
PubChem Substance ID:
24899462
NACRES:
NA.52

Grade

Molecular Biology
for molecular biology

제품 라인

BioReagent

양식

solid

mp

310-311 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

외래 활성

DNase, RNase, protease, NICKase, none detected

저장 온도

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

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일반 설명

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

애플리케이션

Used to precipitate DNA from low salt aqueous buffers.

생화학적/생리학적 작용

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

관련 제품

제품 번호
설명
가격

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCM7828
BCCL7411
BCCK7695
BCCH9915
BCCG9744

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COA 검색

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Sigma-Aldrich

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Sigma-Aldrich

S0266

Spermidine

ODQ A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM).

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Spermidine 0.1 M solution

L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
Aracely A Lutes et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9910-9915 (2011-05-06)
Speciation in animals commonly involves an extrinsic barrier to genetic exchange followed by the accumulation of sufficient genetic variation to impede subsequent productive interbreeding. All-female species of whiptail lizards, which originated by interspecific hybridization between sexual progenitors, are an exception
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프로토콜

Spermine Tetrahydrochloride for Molecular Biology

This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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