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Merck
모든 사진(2)

주요 문서

SAB4502541

Sigma-Aldrich

Anti-CD45 antibody produced in rabbit

affinity isolated antibody

동의어(들):

L-CA, LY-5, Leukocyte common antigen precursor, Leukocyte common antigen variant 4 precursor, Lymphocyte common antigen Ly-5

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

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생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 147 kDa

종 반응성

rat, mouse, human

농도

~1 mg/mL

기술

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

일반 설명

Anti-CD45 antibody detects endogenous levels of total CD45 protein.
The CD45 (cluster of differentiation 45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.

면역원

The antiserum was produced against synthesized peptide derived from human CD45.

Immunogen Range: 981-1030

애플리케이션

Anti-CD45 antibody produced in rabbit has been used in:
  • immunohistochemistry staining[1]
  • immunofluorescence staining[2]
  • immunostaining

생화학적/생리학적 작용

The Cluster of differentiation 45 (CD45) facilitates the regulation of lymphocyte signaling and SRC family kinase Lck. This protein participates in the polymorphism in several mammalian species.
The protein encoded by CD45 (cluster of differentiation 45) is a prototypic receptor and exhibits phosphatase activity. CD45 is found to control T-cell mediated BCR-signaling.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.
Taher TE
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Pancreatic cancer (PC) is a highly malignant tumor type with a high early metastasis rate and no obvious symptoms. Gemcitabine is a first-line chemotherapeutic drug for PC. Since there is no distinct method to determine the efficacy of chemotherapy with
Kristina Spaniol et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(3), 547-557 (2018-02-03)
Limbal epithelial stem cells (LESC) reside in a niche in the corneo-scleral transition zone. Deficiency leads to pain, corneal opacity, and eventually blindness. LESC transplantation of ex-vivo expanded human LESC on a carrier such as human amniotic membrane is a

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